georgiosgiamas

1. The “Hit-and-Run” legacy: epigenetic locking and the survival switch in H. pylori-associated gastric cancer This article introduces a novel "Survival Switch" hypothesis to explain the persistent risk of gastric cancer (GC) even after H. pylori eradication. The review's significance lies in shifting the clinical paradigm from simply eradicating the pathogen to a "Wake-up and Kill" strategy. This involves using epigenetic drugs to reverse the mesenchymal phenotype, thereby re-sensitizing...

Great and huge Chinese lunch with the team (+1)! I'd like to welcome our 2 new PhD students (Hanning and Yuxin), who will officially start their work in September! Looking forward to it! At the same time, I would like to say farewell to Niloufar, and wish her all the best as she embarks on a new PhD chapter abroad!! 🥳 You will always be welcomed in our lab!

Combined multi-omics and multi-spectral profiling of plasma extracellular vesicles reveals liquid biopsy biomarkers for glioma diagnosis New multi-national collaborative study analysing small extracellular vesicles (sEVs) from 206 plasma samples across three independent cohorts (UK, Denmark, NZ), and identifying 45 consistently altered proteins and 20 microRNAs in glioma patients. Our machine learning models achieved AUCs of 0.931-0.971, with 100% accuracy in an independent longitudinal...