georgiosgiamas

AMAZING SURPRISE and delicious cake from my awesome lab members for my xx(?!) birthday!!! THANK YOU all so much. I am so happy and honoured to be working with you!

A Regulatory Element in the Intrinsically Disordered C-Terminal Region of LMTK3 Modulates Its Kinase Domain Interactions and Breast Cancer Phenotypes In this study, we have identified a previously uncharacterised regulatory element within the LMTK3 C-terminus that can modulate its kinase domain interactions and LMTK3-driven oncogenic functions. Ultimately, by understanding and potentially blocking this switch, the study opens up a new avenue for developing therapies that could stop breast...

1. The “Hit-and-Run” legacy: epigenetic locking and the survival switch in H. pylori-associated gastric cancer This article introduces a novel "Survival Switch" hypothesis to explain the persistent risk of gastric cancer (GC) even after H. pylori eradication. The review's significance lies in shifting the clinical paradigm from simply eradicating the pathogen to a "Wake-up and Kill" strategy. This involves using epigenetic drugs to reverse the mesenchymal phenotype, thereby re-sensitizing...